SMPDL3B axis – exploratory patient-led model (not a diagnostic test)
SMPDL3B-Focused Questionnaire
This 10-question tool explores whether your symptom pattern leans toward a
SMPDL3B-shedding phenotype, a SMPDL3B-deficient phenotype,
or a pattern where SMPDL3B biology is not the main driver.
Based on the BA-GLA / SMPDL3B disease concept v2.1. This is research-oriented and
not a medical diagnosis or treatment guide.
How to interpret certain terms
- Salt + water loading – A proper “salt load” usually means roughly
1–2 g sodium (e.g., 2–4 standard 500–600 mg sodium tablets or equivalent salt)
taken with about 500–1000 ml of water over 20–40 minutes, unless medically
contraindicated. A single small salt tablet with a few sips of water is not
a full salt load.
- Vasodilating supplements – e.g., high-dose niacin, citrulline/arginine,
beetroot/nitrate products, or other supplements that noticeably widen blood vessels or make
you feel “flushed” or “opened up.”
- Protein shakes – pea, whey, or casein-based shakes or blends (not pure
collagen) with a typical serving of 15–30 g protein taken as a drink.
- Pre-workout (non-caffeine) – products marketed to boost performance
that do not primarily rely on caffeine (often contain creatine, beta-alanine,
citrulline/arginine, etc.).
- MCAS-like flare – episodes of flushing, burning, itching, swelling,
hives, or feeling “inflamed and reactive” even from small triggers.
This tool is experimental and based on a theoretical disease model (BA-GLA / SMPDL3B axis).
It is not a diagnostic test and should not guide treatment decisions without clinical supervision.