SMPDL3B Pattern Quiz (v2.4)

A short pattern-based quiz to identify SMPDL3B instability dynamics based on symptom timing, variability, and recovery behavior.

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Important note on interpretation

This quiz is a pattern-based assessment tool, not a diagnostic test.

It does not replace laboratory measurement of SMPDL3B activity, expression, or related biomarkers, where such testing is available.

Results reflect behavioral system patterns inferred from symptom timing, variability, and recovery dynamics, and should be interpreted alongside clinical history, physiology, and—when possible—objective testing.

This quiz is intended for research, educational, and self-understanding purposes only, and is not medical advice.

Purpose

This quiz is designed to identify patterns of SMPDL3B instability based on how symptoms fluctuate over time, especially in response to stress, exertion, and recovery. It focuses on system behavior (timing, variability, recovery dynamics), not symptom severity or diagnosis.

What This Quiz Does — and Does Not — Do

This quiz assesses how your system behaves under stress, not how sick you are at baseline. It does not measure:

  • Overall disease severity or disability level
  • Whether symptoms are primarily metabolic, vascular, or autonomic
  • Diagnosis, prognosis, or treatment recommendations

Importantly, SMPDL3B pattern is not the same as symptom burden. Some people experience severe symptoms due to autonomic or vascular instability even when SMPDL3B behavior is episodic, while others have chronically reduced capacity with fewer dramatic crashes. Results describe dominant patterns, not fixed or permanent subtypes.

Important Note for Very Severe or Bed-Bound Illness

If you are currently experiencing near-continuous symptoms with little or no recovery between days, this quiz may be less able to distinguish patterns. In prolonged or severe states, the system can become temporarily “locked” in a flare, making symptoms appear constant rather than episodic.

In these situations:

  • Answer based on earlier phases of your illness, or
  • Periods when some recovery was still possible

Results may be mixed or indeterminate and should be interpreted as pattern guidance, not a fixed classification.

How to Answer

Choose the option that best matches your experience. If unsure, select “Not sure / varies too much to tell.”

Questions

Core (Q1–Q5) required

Question 1 — Immediate response to small triggers

1) With small triggers (light standing, brief conversation, minor stress or positional change), what tends to happen first?

Question 2 — Timing after exertion or stress

2) After a physical, cognitive, or emotional stressor, which pattern best describes your symptoms over the next few days?

Question 3 — Variability over time

3) Over the course of your illness (especially earlier on), how variable was your functional capacity from day to day or week to week?

Question 4 — Predictability with pacing

4) Once you’ve learned your limits and try to pace yourself, how predictable are your symptoms?

Question 5 — Baseline recovery

5) Between crashes or flare-ups, which description best matches your experience (either currently or earlier in your illness)?

Optional Questions

Answer for higher confidence

Question 6 — Recovery-window sensitivity

6) During recovery after a crash, how does your sensitivity to normally tolerable stressors change?

Question 7 — Trigger breadth

7) What types of triggers are most likely to worsen your symptoms?

Result

View details

Results describe dominant patterns, not fixed or permanent subtypes, and are not diagnostic or treatment advice.