This questionnaire explores four layers: baseline load response (Amplifier), deep crash/PEM architecture, SMPDL3B instability style, and GLA / ER-stress context.
This questionnaire looks for patterns in how your body responds to activity, stress, and recovery — not how severe your illness is.
A short interpretation guide appears after your results.
Answer each question based on typical patterns. If you are currently in a continuously flared or very severe state, some answers may reflect earlier phases of illness.
Purpose of this section
These questions identify which physiological system tends to fail first under everyday load.
They are not intended to measure illness severity, recovery capacity, or delayed crashes.
When answering, focus on the earliest and most limiting physical response that appears during or immediately after the activity.
Purpose of this section
These questions describe how your body responds during a full, deep crash after clear overexertion, including
which systems dominate, when the crash peaks, and how recovery unfolds.
This section is not intended to measure baseline function or day-to-day variability.
Answer based on clear crashes, not mild symptom flares.
Purpose of this section
This section explores how your symptoms fluctuate and recover over time, particularly in response to stress or exertion.
It is designed to identify patterns of instability (for example, episodic flares versus persistent baseline impairment),
not illness severity and not which system fails first.
Your answers here may reflect earlier phases of illness if your current state is very severe or continuously flared.
Optional questions — answer for higher confidence
Purpose of this section
This section explores background metabolic, hepatic, and recovery-related stress within the
Gut–Liver–Autonomic (GLA) axis.
These questions provide context for how symptoms are expressed and how recovery feels.
They do not define illness severity, subtype, amplifier pattern, or SMPDL3B phenotype.
Answer based on typical physical responses, not dietary beliefs or intentional strategies.
Tip: you can keep sections collapsed to reduce cognitive load.
Results are shown in separate cards because they measure different layers: Amplifier (what fails first), SMPDL3B instability style (how symptoms fluctuate), and GLA/ER-stress context (terrain).
[Primary amplifier result]
[Short interpretation note]
[Crash pattern + timing]
[Short interpretation note]
[Shedding / deficient / mixed / perfusion-dominant]
[Include Entrained/Locked modifier if detected]
[Low / moderate / significant / high context signal]
[Short interpretation note]
Baseline, deep PEM crashes, and overall mix.
These sections explain what each result card represents and how to interpret them together.
This quiz shows patterns in how your body reacts to activity, stress, and recovery. It does not diagnose anything, measure how sick you are, or predict the future.
You can have different patterns in different sections — this is normal. None of these results mean your symptoms are permanent.
This quiz describes patterns in how your body responds to activity, stress, and recovery. It does not diagnose a condition, measure how sick you are, or predict the future.
Section A — What limits you first
This shows which type of symptom usually appears first during everyday activity: muscles, brain/blood flow, autonomic symptoms (heart rate, breathlessness), or a mix. It is about immediate responses, not crashes that happen later.
Section B — What crashes look like
This describes what happens during a full crash after overdoing it: which symptoms dominate, when the crash peaks, what makes it worse, and what improves first. Delayed crashes (1–3 days later) are common and real.
Section C — How symptoms fluctuate over time
This looks at whether symptoms come in flares with partial recovery, stay more constant, or mainly change based on posture or activity. An “Entrained / Locked” note means recovery is especially difficult right now — not that recovery is impossible.
Section D — Background stress on the system
This gives context about how things like meals, fasting, or demanding days affect you. A higher signal means these factors may shape how crashes feel or resolve — not that they are the cause.
Use this summary to better understand your body and to communicate more clearly with clinicians — not to push beyond your limits.
This questionnaire reports pattern-level information across four distinct layers of physiology. Each section describes a different aspect of how symptoms are expressed, fluctuate, and recover. No single result should be interpreted in isolation.
The Amplifier result describes which physiological system tends to fail first under everyday load, such as light activity, standing, stimulation, or mental effort.
The Amplifier is not a measure of illness severity and does not describe delayed crashes. It reflects baseline load sensitivity — what limits you during or immediately after activity.
This section describes how your body behaves during a full, deep crash after clear overexertion. It captures three independent features:
The timing information is particularly important. A delayed peak (24–72 hours or later) reflects delayed post-exertional physiology, not slow perception or psychological factors.
Section B is intentionally separate from Section A: many people have one baseline Amplifier but crash through a different dominant system.
This section describes how symptoms fluctuate and recover over time, especially in response to stress. It does not describe which system fails first or how severe the illness is.
An Entrained / Locked modifier indicates persistent baseline suppression or loss of recovery capacity. This modifier reflects recovery dynamics, not irreversibility.
This section is pattern-based only and does not replace biomarker testing for SMPDL3B.
Section D provides context about metabolic, hepatic, and recovery-related load within the Gut–Liver–Autonomic (GLA) axis.
A higher context signal suggests that factors such as meal timing, fasting tolerance, post-meal burden, or delayed “toxic/heavy” feelings may influence how crashes feel and resolve. It does not define subtype, illness severity, or cause.
Use these results as a framework for understanding symptom behavior and for more informed discussion with clinicians or researchers — not as a standalone clinical assessment.
These documents provide the research and systems framework that informed this questionnaire. They are optional and intended for clinicians, researchers, and readers seeking deeper context.