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Full Pattern Quiz v2.4

This questionnaire explores four layers: baseline load response (Amplifier), deep crash/PEM architecture, SMPDL3B instability style, and GLA / ER-stress context.

Important: This tool is not diagnostic and does not replace biomarker testing (including SMPDL3B), clinical assessment, or medical advice. Results describe patterns, not severity or prognosis.

How to Use This Quiz

This questionnaire looks for patterns in how your body responds to activity, stress, and recovery — not how severe your illness is.

A short interpretation guide appears after your results.

Quiz

Answer each question based on typical patterns. If you are currently in a continuously flared or very severe state, some answers may reflect earlier phases of illness.

Section A — Baseline Load Response (Amplifier Identification) A1–A8

Purpose of this section
These questions identify which physiological system tends to fail first under everyday load.
They are not intended to measure illness severity, recovery capacity, or delayed crashes.

When answering, focus on the earliest and most limiting physical response that appears during or immediately after the activity.

A1.

After light physical activity (for example, a short walk or basic household chores), which change usually appears first?
(Choose the earliest and most limiting response.)

A2.

When standing still for several minutes (for example, waiting in line or standing at a counter), what tends to limit you first?
(Focus on the earliest response.)

A3.

When climbing a short flight of stairs or walking uphill, what tends to limit you first?

A4.

When you are in busy or stimulating environments (for example, crowds, visual motion, or multiple conversations), what physical response appears first?
(Focus on bodily symptoms rather than emotional reactions.)

A5.

During very light routine activities (such as preparing simple food or light household tasks), what tends to limit you first during the activity itself?

A6.

During emotional stress or sustained mental effort (for example, complex conversations, decision-making, or time pressure), which physical response appears first?

A7.

When you stand up quickly from sitting or lying down, what happens within the first few seconds?
(Choose the most immediate response.)

A8.

When you exceed your usual activity level (moderate exertion such as longer walking, carrying items, or sustained activity), what tends to worsen first within about 2–6 hours afterward?
(Focus on early post-activity changes, not next-day crashes.)

Section B — Deep Crash & Post-Exertional Malaise (PEM) Architecture B1–B4

Purpose of this section
These questions describe how your body responds during a full, deep crash after clear overexertion, including which systems dominate, when the crash peaks, and how recovery unfolds.

This section is not intended to measure baseline function or day-to-day variability.
Answer based on clear crashes, not mild symptom flares.

B1.

During a full, deep PEM crash after clear overexertion, which pattern best describes your symptoms overall?
(Choose the pattern that dominates the crash, even if other symptoms are also present.)

B2.

After clear overexertion, when does a full, deep crash usually reach its worst point?
(Think of when symptoms are at their peak, not the first hint of worsening.)

B3.

When you are already in a full crash, which factor most reliably makes your symptoms noticeably worse in the moment?

B4.

After a major crash, how do your symptoms usually improve over the following 1–3 weeks?
(Choose the system that tends to stabilize first; others may lag behind.)

Section C — SMPDL3B Instability Pattern (Style of Symptom Fluctuation) C1–C7

Purpose of this section
This section explores how your symptoms fluctuate and recover over time, particularly in response to stress or exertion.
It is designed to identify patterns of instability (for example, episodic flares versus persistent baseline impairment), not illness severity and not which system fails first.

Your answers here may reflect earlier phases of illness if your current state is very severe or continuously flared.

C1.

With small triggers (such as light standing, brief conversation, minor stress, or a positional change), what tends to happen first?

C2.

After a physical, cognitive, or emotional stressor, which pattern best describes your symptoms over the next few days?

C3.

Over the course of your illness (especially earlier on), how variable was your functional capacity from day to day or week to week?

C4.

Once you have learned your limits and try to pace yourself, how predictable are your symptoms?

C5.

Between crashes or flare-ups, which description best matches your experience (either currently or earlier in your illness)?

Optional questions — answer for higher confidence

C6. (Optional)

During recovery after a crash, how does your sensitivity to normally tolerable stressors change?

C7. (Optional)

What types of triggers are most likely to worsen your symptoms?

Section D — GLA / ER-Stress Context (Metabolic & Recovery Terrain) D1–D4

Purpose of this section
This section explores background metabolic, hepatic, and recovery-related stress within the Gut–Liver–Autonomic (GLA) axis.

These questions provide context for how symptoms are expressed and how recovery feels. They do not define illness severity, subtype, amplifier pattern, or SMPDL3B phenotype.

Answer based on typical physical responses, not dietary beliefs or intentional strategies.

D1.

If you skip breakfast or remain unfed in the morning (before eating), how does your body usually feel?
(Focus on physical symptoms rather than hunger, mood, or caffeine effects.)

D2.

After a typical meal, how does your body usually respond within the first 1–3 hours?
(Focus on overall physical effects rather than stomach discomfort alone.)

D3.

When you eat a richer or higher-fat meal than usual, how does your body typically respond within the next few hours?
(Focus on overall physical effects, not digestive symptoms alone.)

D4.

After physical, cognitive, or metabolic stress (such as exertion, prolonged activity, or a demanding day), do you experience a delayed period of feeling systemically unwell or “toxic”?
(This question is not asking about classic delayed PEM.)

Tip: you can keep sections collapsed to reduce cognitive load.

Your Results

Results are shown in separate cards because they measure different layers: Amplifier (what fails first), SMPDL3B instability style (how symptoms fluctuate), and GLA/ER-stress context (terrain).

OVERALL PATTERN
[Overall pattern summary]
Amplifier: [A] Crash: [B] SMPDL3B: [C] GLA: [D]

Amplifier Pattern (Section A)

[Primary amplifier result]

[Short interpretation note]

Crash / PEM Architecture (Section B)

[Crash pattern + timing]

[Short interpretation note]

SMPDL3B Instability Style (Section C)

[Shedding / deficient / mixed / perfusion-dominant]

[Include Entrained/Locked modifier if detected]

GLA / ER-Stress Context (Section D)

[Low / moderate / significant / high context signal]

[Short interpretation note]

Amplifier pattern (M1–M3)

Baseline, deep PEM crashes, and overall mix.

Baseline (Section A)
Deep crash (Section B)
Overall mix (A + B)
View amplifier interpretation

How to Read Your Results

These sections explain what each result card represents and how to interpret them together.

Too tired? Read this only. Very short

This quiz shows patterns in how your body reacts to activity, stress, and recovery. It does not diagnose anything, measure how sick you are, or predict the future.

You can have different patterns in different sections — this is normal. None of these results mean your symptoms are permanent.

Patient Summary Plain language

This quiz describes patterns in how your body responds to activity, stress, and recovery. It does not diagnose a condition, measure how sick you are, or predict the future.

Section A — What limits you first

This shows which type of symptom usually appears first during everyday activity: muscles, brain/blood flow, autonomic symptoms (heart rate, breathlessness), or a mix. It is about immediate responses, not crashes that happen later.

Section B — What crashes look like

This describes what happens during a full crash after overdoing it: which symptoms dominate, when the crash peaks, what makes it worse, and what improves first. Delayed crashes (1–3 days later) are common and real.

Section C — How symptoms fluctuate over time

This looks at whether symptoms come in flares with partial recovery, stay more constant, or mainly change based on posture or activity. An “Entrained / Locked” note means recovery is especially difficult right now — not that recovery is impossible.

Section D — Background stress on the system

This gives context about how things like meals, fasting, or demanding days affect you. A higher signal means these factors may shape how crashes feel or resolve — not that they are the cause.

  • These results describe patterns, not diagnoses.
  • You can have different patterns in different sections — this is normal.
  • Patterns can change with time, illness stage, or treatment.
  • No result means symptoms are permanent.

Use this summary to better understand your body and to communicate more clearly with clinicians — not to push beyond your limits.

Detailed Summary How to interpret

This questionnaire reports pattern-level information across four distinct layers of physiology. Each section describes a different aspect of how symptoms are expressed, fluctuate, and recover. No single result should be interpreted in isolation.

Section A — Amplifier Pattern (Baseline Load Response)

The Amplifier result describes which physiological system tends to fail first under everyday load, such as light activity, standing, stimulation, or mental effort.

  • M1 — Metabolic / muscle-dominant: early muscle heaviness, weakness, or fatigue appears before other symptoms.
  • M2 — Vascular / perfusion-dominant: head pressure, lightheadedness, brain fog, or visual dimming appear first.
  • M3 — Autonomic / low-volume-dominant: heart-rate instability, breathlessness, shakiness, or internal agitation appear first.
  • Mixed amplifier: more than one system tends to worsen at the same time, or the dominant system varies by context.

The Amplifier is not a measure of illness severity and does not describe delayed crashes. It reflects baseline load sensitivity — what limits you during or immediately after activity.

Section B — Crash / PEM Architecture

This section describes how your body behaves during a full, deep crash after clear overexertion. It captures three independent features:

  • Dominant crash pattern: which system dominates during the crash.
  • Timing: when the crash reaches its worst point after exertion.
  • Modifiers: what worsens symptoms during the crash and which systems recover first.

The timing information is particularly important. A delayed peak (24–72 hours or later) reflects delayed post-exertional physiology, not slow perception or psychological factors.

Section B is intentionally separate from Section A: many people have one baseline Amplifier but crash through a different dominant system.

Section C — SMPDL3B Instability Style

This section describes how symptoms fluctuate and recover over time, especially in response to stress. It does not describe which system fails first or how severe the illness is.

  • Shedding-dominant pattern: episodic flares with variability and at least partial baseline return between episodes.
  • Deficient-dominant pattern: persistent baseline impairment with slower or incomplete recovery and fewer true “good days.”
  • Mixed / transitional pattern: overlapping features of both, often influenced by illness stage or amplifier dominance.
  • Non-SMPDL3B dominant (Amplifier-driven): symptoms track posture or immediate load more directly than flare–recovery cycles.

An Entrained / Locked modifier indicates persistent baseline suppression or loss of recovery capacity. This modifier reflects recovery dynamics, not irreversibility.

This section is pattern-based only and does not replace biomarker testing for SMPDL3B.

Section D — GLA / ER-Stress Context

Section D provides context about metabolic, hepatic, and recovery-related load within the Gut–Liver–Autonomic (GLA) axis.

A higher context signal suggests that factors such as meal timing, fasting tolerance, post-meal burden, or delayed “toxic/heavy” feelings may influence how crashes feel and resolve. It does not define subtype, illness severity, or cause.

Important Interpretation Notes

  • These results describe patterns, not diagnoses.
  • Results may reflect earlier phases of illness if you are currently very severe, continuously flared, or rarely return toward baseline.
  • Amplifier pattern, SMPDL3B instability style, and crash architecture are independent layers and should be interpreted together.
  • No single result implies prognosis, permanence, or treatment recommendations.

Use these results as a framework for understanding symptom behavior and for more informed discussion with clinicians or researchers — not as a standalone clinical assessment.

Notes & Limitations Important
  • Patterns, not diagnosis: These results describe symptom patterns. They are not a medical diagnosis and do not replace clinical evaluation.
  • Not a severity score: A “more intense” result does not automatically mean “more severe illness.” Sections A–D measure different layers, not overall sickness level.
  • Context matters: Results can shift with sleep, dehydration, heat, infection, hormones, stress, medication changes, and recovery window.
  • Illness stage can blur patterns: If you are continuously flared, very severe, or rarely return toward baseline, your answers may reflect a flattened stage rather than your earlier pattern.
  • Mixed results are common: It is normal to show one baseline Amplifier (Section A) but crash through a different dominant system (Section B), or to show a mixed instability style (Section C).
  • Section C is pattern-based only: “Shedding-like / deficient-like” labels describe timing and recovery dynamics. This quiz does not replace a laboratory biomarker test for SMPDL3B.
  • Entrained / Locked is not a prognosis: This modifier indicates reduced recovery capacity in the current window. It does not imply permanence or irreversibility.
  • Use the results safely: Do not use quiz results to justify pushing limits, testing exertion, or changing medications. Use them to improve pacing decisions and communication with clinicians/researchers.